Neuroscience was my first love and has remained my longest sustained research interest, with a focus on the molecular mechanisms of learning and memory – and as a strategic approach to that subject, molecular changes during neural development. My significant contributions to the field have included:
Below are my major publications in neuroscience, with notable contributions to the field indicated by asterisks.
*Irwin, L.N. 2021. Scotophobin: Darkness at the Dawn of the Search for Memory Molecules. Xlibris, Bloomington IN
*Irwin, L. N. 2020. Haystack Full of Needles: A memoir of research on mechanisms of memory in the decades that defined neuroscience. Xlibris, Bloomington IN
CHAPTERS AND REVIEWS
Ungar G. and L. N. Irwin. 1968. Chemical correlates of neural function. Neurosci. Res. 1:73-142.
Irwin, L.N. 1974. Glycolipids and glycoproteins in brain function. Rev. Neurosci. 1:137-179.
ESSAYS AND COMMENTARIES
*Irwin, L.N. 1978. Fulfillment and frustration: the confessions of a behavioral biochemist. Perspect Biol Med 21:476-491. (This essay was awarded First Prize in the international writing competition for Perspectives authors in 1978).
Irwin, L.N. 1992. Acrobat to academic: a sketch of the life and career of Frederick E. Samson, Jr. Neurochem. Res. 17:5-10.
Ungar G. and L.N. Irwin. 1967. Transfer of acquired information by brain extracts. Nature214:453-455.
Irwin, L.N. 1969. Biochemical changes in subcellular fractions of brains of stimulated rats. Brain. Res. 15:518-521.
Irwin, L.N. and F.E. Samson. 1971. Content and turnover of gangliosides in rat brain following behavioral stimulation. J. Neurochem. 18:203-211.
Irwin, L.N., J. Mancini, and D. Hills. 1973. Sialidase activity against endogenous substrate in rat brain. Brain. Res. 53:488-491.
*Gray, D.B. and L.N. Irwin. 1973. developmental changes in sialic acid content of the optic tectum of chick embryos. J. Neurobiol. 4:487-490.
*Irwin, L.N., H. Chen, and R.A. Barraco. 1976. Ganglioside, protein, hexose, and sialic acid changes during development of the trisected optic tectum of the chick embryo. Develop. Biol. 49:29-39.
Barraco, R.A. and L.N. Irwin. 1976. Cerebral protein patterns from trained and naive pigeons. J. Neurochem. 27:393-397.
*Barraco, R.A., B.J. Klauenberg and L.N. Irwin. 1978. Swim escape: a multicomponent, one-trial learning task. Behav. Biol. 22:114-121.
Irwin, L.N., R.A. Barraco and D. Terrian. 1978. Protein and glycoprotein metabolism in brains of operantly conditioned pigeons. Neuroscience 3:457-464.
*Irwin, L.N. and D.M. Terrian. 1978. Glucosamine incorporation into brain glycoproteins and gangliosides: effect of adrenalectomy, corticosterone, exercise, and training. Pharmac. Biochem. 9:33-37.
*Irwin, C.C. and L.N. Irwin. 1979. A rapid simple procedure for ganglioside isolation from small amounts of tissue. Analyt. Biochem. 94:335-339.
*Irwin, L.N. and C.C. Irwin. 1979. Developmental changes in ganglioside composition of hippocampus, retina, and optic tectum. Develop. Neurosci. 2:129-138.
*Irwin, L.N., D. Michael, and C.C. Irwin. 1980. Ganglioside patterns of fetal rat and mouse. J. Neurochem. 34:1527-1530.
*Irwin, L.N. and C.C. Irwin. 1982. Developmental changes and regional variation in the ganglioside composition of the rat hippocampus. Develop. Brain. Res.4:481-485.
Irwin, L.N., G.D. Hunter, J.E. Crandall, and R.H. McClure. 1985. Ganglioside patterns during cerebral development in the normal and reeler mouse. J. Neurosci. Res.13:591-597.
Irwin, L.N., E.G. Bremer, C.C. Irwin and R.H. McCluer. 1985. Developmental variation in monosialoganglioside content of embryonic chick retina and tectum. Devel. Neurosci. 7:239-246.
Wolf, L. and L.N. Irwin. 1992. Potassium-induced depolarization displaces exogenous gangliosides from hippocampal slices. Brain Res. 582:346-348.
Young, H., Z Christian, R. Cabeza, and L.N. Irwin. 1998. Exogenous ganglioside uptake by synaptosomal membranes: effect of proteolytic enzymes. Neurochem. Res. 23: 1515-1520.
*Irwin, L.N. 2001. Gene expression in the hippocampus of behaviorally stimulated rats: analysis by DNA microarray. Mol. Brain Res. 96(1-2): 163-9
*Byers D.M., L.N. Irwin, R. Cabeza. 2002. Ganglioside patterns mature at different rates in functionally related subregions of the rat pons. Develop. Neurosci. 24: 478-484.
Sumaya, I.C., D.M. Byers, L.N. Irwin, S. Del Val, D.E. Moss. 2004. Circadian-dependent effect of melatonin on dopaminergic D2antagonist-induced stereotypies in rats. Pharmacol. Biochem. Behav. 78:727-733.
*Michael D.B., Byers D.M., Irwin L.N. 2005. Gene expression following traumatic brain injury in humans: analysis by microarray. J. Clin. Neurosci. 12: 284-290.
*Byers, D. M., L. N. Irwin, D. E. Moss, I. C. Sumaya, C. F. Hohmann. 2005. Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression. Develop. Brain Res. 158(1-2): 13-22.
*Liang, S, D. M. Byers, L. N. Irwin. 2007. Chronic mild stressors and diet affect gene expression differently in male and female rats. J. Molec. Neurosci. 33:189-200. 10.1007/s12031-007-0064-x).
*Liang, S, D. M. Byers, L. N. Irwin. 2008. Sex and diet affect the behavioral response of rats to chronic mild stressors. Physiol. Behav. 93: 27-36.
*Byers, D. M., J.G. Gorbet, L. N. Irwin. 2011. Disialogangliosides and TNF-alpha alter gene expression for cytokines and chemokines in primary brain cell cultures. Neurochem Res. 37(1), 214-222. http://dx. doi 10.1007/s11064-011-0587-y
*Irwin, L.N. & D.M. Byers. 2012. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Brain Res.1489: 1-7 (2012) http://dx.doi.org/10.1016/j.brainres.2012.10.034
*Christian, Z.F., P.D. Craig, K. Rayburn, and L.N. Irwin. 2018. Effect of exercise in combination with dietary nopal and zucchini on chronic and acute glucohomeostasis in genetically obese mice. Intl. J. Exp. Biol. 1:1-5. https://www.researchgate.net/publication/328430390
*Irwin, L. N. 2020. Renewed perspectives on the deep roots and broad distribution of animal consciousness. Front. Syst. Neurosci.14. https://doi.org/10.3389/fnsys.2020.00057
*Irwin, L.N. and B.A. Irwin. 2020. Place and environment in the ongoing evolution of cognitive neuroscience. J. Cogn. Neurosci. 32: 1837-1850. https://doi.org/10.1162/jocn_a_01607